Efficacy and tolerability of a once daily formulation of Ginkgo biloba extract EGb 761® in Alzheimer's disease and vascular dementia: results from a randomised controlled trial.
Pharmacopsychiatry. 2012 Mar;45(2):41-6
Authors: Ihl R, Tribanek M, Bachinskaya N, GOTADAY Study Group
INTRODUCTION: A 24-week randomised controlled trial was
conducted to assess the efficacy of a 240 mg once-daily preparation of
Ginkgo biloba extract EGb 761® in 404 outpatients ≥ 50 years diagnosed
with mild to moderate dementia (SKT 9-23), Alzheimer's disease (AD) or
vascular dementia (VaD), with neuropsychiatric features (NPI total score
METHODS: Separate analyses were performed for diagnostic subgroups (probable or possible AD; VaD).
RESULTS: 333 patients were diagnosed with AD and 71 with VaD.
EGb 761® treatment was superior to placebo with respect to the SKT total
score (drug-placebo differences: 1.7 for AD, p<0.001, and 1.4 for
VaD, p<0.05) and the NPI total score (drug-placebo differences: 3.1
for AD, p<0.001 and 3.2 for VaD, p<0.05). Significant drug-placebo
differences were found for most secondary outcome variables with no
major differences between AD and VaD subgroups. Rates of adverse events
in EGb 761® and placebo groups were essentially similar.
CONCLUSION: EGb 761® improved cognitive functioning,
neuropsychiatric symptoms and functional abilities in both types of
PMID: 22086747 [PubMed - indexed for MEDLINE