Saturday, 31 August 2013

The effect of acute café latte ingestion on fasting serum lipid levels in healthy individuals.

The effect of acute café latte ingestion on fasting serum lipid levels in healthy individuals.
J Clin Lipidol. 2013 Mar-Apr;7(2):165-8
Authors: Zargar A, Auttapibarn C, Hong SH, Larson TJ, Hayworth KH, Ito MK
Abstract
BACKGROUND: Many patients drink café latte as part of their habitual morning routine to start their day and may be unable to skip this step before drawing a fasting blood sample for cholesterol testing. However, it is unknown what the acute effects of consuming a café latte are on fasting serum lipids just before blood sampling.
OBJECTIVE: This was a prospective, open-label study with the primary objective of evaluating the acute effect of a 12-oz café latte (2% milk) on calculated low-density lipoprotein cholesterol (LDL-C) and secondary objectives of triglyceride, total cholesterol, high-density lipoprotein cholesterol (HDL-C), non-HDL-C, and fasting blood glucose (FBG).

Friday, 30 August 2013

Bilberry and blueberry anthocyanins act as powerful intracellular antioxidants in mammalian cells.

Bilberry and blueberry anthocyanins act as powerful intracellular antioxidants in mammalian cells.
Food Chem. 2012 Oct 15;134(4):1878-84
Authors: Bornsek SM, Ziberna L, Polak T, Vanzo A, Ulrih NP, Abram V, Tramer F, Passamonti S
Abstract
Berry anthocyanins have pronounced health effects, even though they have a low bioavailability. The common mechanism underlying health protection is believed to relate to antioxidant activity. Berry extracts, chemically characterised for their phenolic content, were prepared from bilberries (Vaccinium myrtillusL.) and blueberries (Vaccinium corymbosumL.); the bilberry extract was further purified to obtain the anthocyanin fraction. The antioxidant activity of each extract was examined at the cellular level. For this purpose a specific assay, known as cellular antioxidant activity assay (CAA), was implemented in different cell lines: human colon cancer (Caco-2), human hepatocarcinoma (HepG2), human endothelial (EA.hy926) and rat vascular smooth muscle (A7r5). Here we show for the first time that anthocyanins had intracellular antioxidant activity if applied at very low concentrations (<1 μg/l; nM range), thereby providing a long-sought rationale for their health protecting effects in spite of their unfavorable pharmacokinetic properties.

Thursday, 29 August 2013

Anti-influenza A virus effects of fructan from Welsh onion (Allium fistulosum L.).

Anti-influenza A virus effects of fructan from Welsh onion (Allium fistulosum L.).
Food Chem. 2012 Oct 15;134(4):2164-8
Authors: Lee JB, Miyake S, Umetsu R, Hayashi K, Chijimatsu T, Hayashi T
Abstract
A fructan that acts as an anti-influenza A virus substance was isolated from hot water extract of the green leafy part of a Welsh onion (Allium fistulosum L.). The structure of the fructan was characterised and elucidated by chemical and spectroscopic analyses. The fructan was composed of terminal (21.0%) and 2,1-linked β-D-Fruf residues (65.3%) with 1,6-linked β-D-Glcp residues (13.7%). The molecular weight of the polysaccharide and polydispersity was estimated to be 1.5×10(3) and 1.18, respectively. Although the fructan did not show anti-influenza A virus activity in vitro, it demonstrated an inhibitory effect on virus replication in vivo when it was orally administered to mice. In addition, the polysaccharide enhanced the production of neutralising antibodies against influenza A virus. Therefore, the antiviral mechanism of the polysaccharide seemed to be dependent on the host immune system, i.e., enhancement of the host immune function was achieved by the administration of the polysaccharide. From our observations, the fructan from Welsh onions is suggested to be one of the active principles which exert an anti-influenza virus effect.

Wednesday, 28 August 2013

Molecular network and chemical fragment-based characteristics of medicinal herbs with cold and hot properties from Chinese medicine.

 2013 Jul 30;148(3):770-9. doi: 10.1016/j.jep.2013.04.055. Epub 2013 May 20.

Molecular network and chemical fragment-based characteristics of medicinal herbs with cold and hot properties from Chinese medicine.

Source

Institute of Basic Research In Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing 100700, China; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Chinese herbal medicines (HMs) is one of the great herbal systems of the world, which play an important role in current health care system in many countries. In the view of tradition Chinese medicine (TCM) theory, Yin-yang and five-elements theory is the central theory, which is used to explain how the world and body work. Under the guidance of such philosophy, TCM considers that HMs have different properties, which are the important factors for prescribing herbal formulae; such prescriptions are based on TCM pattern classification in clinical practice. The cold and hot property are commonly defined for HM property identification; however, the biological activities that are related to the HM property remain a mystery because of a lack of appropriate methods. A bioinformatics approach was applied to identify the distinguishing biological activities of HMs that have these cold and hot properties.

Tuesday, 27 August 2013

Analysis on dosage of traditional Chinese medicine decoction pieces stipulated in Chinese pharmacopoeia.

Analysis on dosage of traditional Chinese medicine decoction pieces stipulated in Chinese pharmacopoeia.
Zhongguo Zhong Yao Za Zhi. 2013 Apr;38(7):1095-7
Authors: Ji HY, Chen XY, Jiao YZ, Tong XL
Abstract
Chinese Pharmacopoeia I (2010 edition) covers dosage and usage of traditional Chinese medicinal herbs and decoction pieces, and provides dosage ranges of most of decoction pieces. By using the descriptive statistical method, the article discusses the distribution of maximum dosage, minimum dosage and dosage range of decoction pieces set forth in Chinese Pharmacopoeia, and compares toxic drugs and non-toxic drugs. Altogether 617 drugs are included into the study. Except for 16 decoction pieces whose dosages are not clear, all of the remaining decoction pieces are covered by Chinese Pharmacopoeia, with the maximum common dosage, minimum common dosage and dosage range of 3, 10 and 6 g. Upon comparison, we discovered that Chinese Pharmacopoeia sets stricter standards for toxic drugs than non-toxic drugs. Compared with dosages in classical prescriptions and actual clinical usages, dosage ranges described in Chinese Pharmacopoeia are much narrower. There is no significant difference between drugs that can be used as foods or healthcare foods and other drugs according to Chinese Pharmacopoeia.

Monday, 26 August 2013

Efficacy observation on acupuncture and moxibustion combined with hot compress of TCM herbs for scleroderma.

Efficacy observation on acupuncture and moxibustion combined with hot compress of TCM herbs for scleroderma.
Zhongguo Zhen Jiu. 2013 May;33(5):403-6
Authors: Yan XN, Zhang JR, Zhang CQ, Tian Q, Chen L, Chen L
Abstract
OBJECTIVE: To assess the clinical efficacy and safety of surrounding needle, moxibustion and hot compress of TCM herbs for localized scleroderma.
METHODS: Forty-two cases of localized scleroderma were randomly divided into an acupuncture + herb group (23 cases, group A) and a heparin sodium group (19 cases, group B). Both the two groups were orally administrated with centella triterpenes tablets and vitamin E, group A was additionally treated with surrounding needle at local area, moxibustion at affected site and Hegu (LI 4), Zu sanli (ST 36) as well as hot external application of "hot compress herbs" at local location, while group B was treated with external application of heparin sodium cream. Both the two groups were treated for consecutive 6 months, and scores of skin sclerosis, joint pain and function were compared before and after the treatment. Also the efficacy and safety of TCM syndrome were assessed.
RESULTS: Compared with that before the treatment, the scores of skin sclerosis, joint pain and joint function in the group A after treatment were significantly decreased (all P < 0.01), the score of skin sclerosis in the group B was improved (P < 0.05), and the three types of score in the group A was obviously lower than those in the group B (both P < 0.05). The total effective rate was 86.4% (19/22) in the group A, which was superior to 52.6% (10/19) in the group B (P < 0.05).
CONCLUSION: The surrounding needle, moxibustion and external application of "hot compress herbs" could improve skin sclerosis in patients with localized scleroderma, which has obvious efficacy and relative safety.
PMID: 23885611 [PubMed - indexed for MEDLINE

Sunday, 25 August 2013

The effectiveness of Echinacea extract or composite glucosamine, chondroitin and methyl sulfonyl methane supplements on acute and chronic rheumatoid arthritis rat model.

The effectiveness of Echinacea extract or composite glucosamine, chondroitin and methyl sulfonyl methane supplements on acute and chronic rheumatoid arthritis rat model.
Toxicol Ind Health. 2013 Mar;29(2):187-201
Authors: Arafa NM, Hamuda HM, Melek ST, Darwish SK
Abstract
The study aimed to investigate the effect of the oral administration for 15 days of either Echinacea (E) or genuphil (a composite of chondroitin sulphate, glucosamine and methyl sulfonyl methane [GCM]) nutraceutical supplements on female rat model of acute or chronic arthritis induced by bacterial outer membrane protein (OMP) from faecal flora of healthy and rheumatic humans. Anti-cyclic citrullinated peptide (anti-CCP2), C-reactive protein (CRP) and rheumatoid factor (RF) values increased (p < 0.05) in both arthritic groups as compared to normal values.

Saturday, 24 August 2013

Being a botanist and a gardener: using diagnostic frameworks in general practice patients with medically unexplained symptoms.

Being a botanist and a gardener: using diagnostic frameworks in general practice patients with medically unexplained symptoms.
Aust J Prim Health. 2013;19(2):90-7
Authors: Stone L
Abstract
Patients with multiple medically unexplained symptoms commonly seek treatment in primary care. Many of these patients seem to have a psychological 'core' to their illness that affects the way they experience, conceptualise and communicate their distress. There is considerable debate around diagnosis for this group of patients. Existing diagnoses include somatoform disorders in psychiatry and functional disorders in the medical specialties. Some clinicians use the term 'heartsink' patients, which reflects the interpersonal frustration inherent in some therapeutic relationships.

Friday, 23 August 2013

Complementary therapies in cystic fibrosis: nutritional supplements and herbal products.

Complementary therapies in cystic fibrosis: nutritional supplements and herbal products.
J Pharm Pract. 2013 Feb;26(1):14-7
Authors: Braga SF, Almgren MM
Abstract
Cystic fibrosis is one of the most common autosomal recessive genetic disorders in caucasians of Northern European descent, affecting approximately 30 000 children and adults living in the United States, today. Complications of this chronic disease result in deterioration of lung function and development of pancreatic abnormalities requiring pharmacological therapy and may include patients seeking complementary and alternative option for treatment. Health care professionals should be knowledgeable of these therapies to effectively provide education and drug therapy management. This article offers an overview of the most common complementary therapies in cystic fibrosis such as vitamin A, vitamin C, vitamin E, zinc, omega 3 fatty acids, docosahexaenoic acid (DHA), garlic, ginseng, and curcumin

Thursday, 22 August 2013

Ginkgo biloba extract EGb 761 in the treatment of dementia: a pharmacoeconomic analysis of the Austrian setting.

Ginkgo biloba extract EGb 761 in the treatment of dementia: a pharmacoeconomic analysis of the Austrian setting.
Wien Klin Wochenschr. 2013 Jan;125(1-2):8-15
Authors: Rainer M, Mucke H, Schlaefke S
Abstract
OBJECTIVE: We used efficacy data from three clinical trials to investigate the pharmacoeconomic implications of treating noninstitutionalized Austrian dementia patients with a drug based on EGb 761R, a standardized extract from Gingkgo biloba. In a separate analysis, we compared the pharmacoeconomic aspects of achieving treatment success with EGb 761R and cholinesterase inhibitors.
METHODS: A fixed-effect model was used to conduct a metaanalysis of activities of daily living data from 1,201 patients diagnosed with dementia and treated with either EGb 761R (240 mg/day) or matched placebo for 22 or 24 weeks under double-blind conditions.

Wednesday, 21 August 2013

Secondary metabolites of Capsicum species and their importance in the human diet.

Secondary metabolites of Capsicum species and their importance in the human diet.
J Nat Prod. 2013 Apr 26;76(4):783-93
Authors: Wahyuni Y, Ballester AR, Sudarmonowati E, Bino RJ, Bovy AG
Abstract
The genus Capsicum (pepper) comprises a large number of wild and cultivated species. The plants are grown all over the world, primarily in tropical and subtropical countries. The fruits are an excellent source of health-related compounds, such as ascorbic acid (vitamin C), carotenoids (provitamin A), tocopherols (vitamin E), flavonoids, and capsaicinoids. Pepper fruits have been used for fresh and cooked consumption, as well as for medicinal purposes, such as treatment of asthma, coughs, sore throats, and toothache. Depending on its uses, there are several main characters important for product quality; pungency, bright attractive colors, highly concentrated extracts, and a small number of seeds are the main characters on which quality is based and priced. Herein, a general overview of biochemical composition, medical properties of these compounds, and characteristics of quality attributes of pepper fruits is presented. 

Tuesday, 20 August 2013

Rosmarinic Acid as a Novel Agent in the Treatment of Autoimmune Disease

Rosmarinic Acid as a Novel Agent in the Treatment of Autoimmune Disease

Aug 12, 2013 03:00 am | Journal of Restorative Medicine

Autoimmune diseases are among the most challenging to treat. Conventional medical therapies are immunosuppressive agents that suppress symptoms, but also have undesirable side effects. An effective alternative therapy without these side effects would be extremely valuable. Rosmarinic acid, which has been used in multiple sclerosis and thyroid autoimmune disease, may be such an alternative therapy.

Monday, 19 August 2013

LDL-cholesterol-lowering effect of a dietary supplement with plant extracts in subjects with moderate hypercholesterolemia

LDL-cholesterol-lowering effect of a dietary supplement with plant extracts in subjects with moderate hypercholesterolemia.
Eur J Nutr. 2013 Mar;52(2):547-57
Authors: Ogier N, Amiot MJ, Georgé S, Maillot M, Mallmann C, Maraninchi M, Morange S, Lescuyer JF, Peltier SL, Cardinault N
Abstract
PURPOSE: Red yeast rice (RYR), sugar cane-derived policosanols (SCdP) and artichoke leaf extracts (ALEs) are currently incorporated alone or in combination into dietary supplements for their potential low-density-lipoprotein cholesterol (LDL-cholesterol)-lowering effects. Yet, there is no information supporting the efficacy of this association on the reduction in LDL-cholesterol. The main objective of this study was to investigate the effects of a new dietary supplement (DS) with RYR, SCdP and ALEs on LDL-cholesterol.

Saturday, 17 August 2013

The influence of aqueous extracts of selected Potentilla species on normal human colon cells.

The influence of aqueous extracts of selected Potentilla species on normal human colon cells.
Acta Pol Pharm. 2013 May-Jun;70(3):523-31
Authors: Tomczyk M, Paduch R, Wiater A, Pleszczyńska M, Kandefer-Szerszeń M, Szczodrak J
Abstract
Potentilla L. (Rosaceae) species have been used in traditional medicine in Asia, Europe and Northern America. This study analyzed the biological activity of aqueous extracts of Potentilla species (Rosaceae): Dasiphora fruticosa (syn. P. fruticosa), P. norvegica, P. pensylvanica, P. thuringiaca, P. crantzii and P. nepalensis.

Friday, 16 August 2013

Occupational asthma associated to the exposure to limonium tataricum flowers.


Occupational asthma associated to the exposure to limonium tataricum flowers.
Eur Ann Allergy Clin Immunol. 2013 May;45(3):84-9
Authors: Ariano R, Mistrello G, Agazzi A, Melioli G
Abstract
Limonium tataricum (Lt) is a plant belonging to the family of Plumbaginaceae. The role of this family and in particular, that of dried flowers (but not of the pollen) in occupational allergy has already been described. We have observed a farmer with asthma occurring in the presence of fresh flowers. Standard methacoline test demonstrated that the patient was a true asthmatic.

Thursday, 15 August 2013

Preliminary evaluation for cancer chemopreventive and cytotoxic potential of naturally growing ethnobotanically selected plants of Pakistan.


Preliminary evaluation for cancer chemopreventive and cytotoxic potential of naturally growing ethnobotanically selected plants of Pakistan.
Pharm Biol. 2013 Mar;51(3):316-28
Authors: Ihsan-ul-Haq, Mirza B, Kondratyuk TP, Park EJ, Burns BE, Marler LE, Pezzuto JM
Abstract
CONTEXT: Natural products are a very productive source of leads for the development of medicines. Six Pakistani plants were chosen for study based on ethnobotanical data.
OBJECTIVE: Exploration of important medicinal plants of Pakistan for cancer treatment.

Wednesday, 14 August 2013

Antioxidant activity and cytotoxicity of Cyrtosperma johnstonii extracts on drug sensitive and resistant leukemia and small cell lung carcinoma cells.

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This lovely image was taken from the Encyclopedia of Life.
http://eol.org/pages/1111964/details

Antioxidant activity and cytotoxicity of Cyrtosperma johnstonii extracts on drug sensitive and resistant leukemia and small cell lung carcinoma cells.
Pharm Biol. 2013 Mar;51(3):329-38
Authors: Okonogi S, Khonkarn R, Mankhetkorn S, Unger FM, Viernstein H
Abstract
CONTEXT: The number of patients with cancer is increasing. New therapeutic agents to overcome drug-resistant tumors are urgently needed. Cyrtosperma johnstonii N.E. Br. (Araceae) is used for treatment of cancer in Thai traditional medicine. This study aimed to evaluate antioxidant activity and cytotoxicity of C. johnstonii extracts on human cancer cells.

Tuesday, 13 August 2013

Larch arabinogalactan effects on reducing incidence of upper respiratory infections

Larch arabinogalactan effects on reducing incidence of upper respiratory infections.
Curr Med Res Opin. 2013 Mar;29(3):251-8
Authors: Riede L, Grube B, Gruenwald J
Abstract
OBJECTIVE: Larch arabinogalactan (ResistAid * ) may prevent cold infections due to its immune-stimulatory properties. In a placebo-controlled, double-blind, randomized clinical trial, the effect of a proprietary larch arabinogalactan preparation on the incidences of common colds and its effect on cold symptoms, as a well established model for immune function, was compared to placebo.
RESEARCH DESIGN AND METHODS: A total of 199 healthy participants who had a self reported cold infection rate of three in 6 months were randomly assigned to receive a total of either 4.5 g of an arabinogalactan preparation (n = 101) or placebo (n = 98) over a period of 12 weeks.

Monday, 12 August 2013

Dietary patterns and the risk of hip fractures in elderly Chinese: a matched case-control study.

Dietary patterns and the risk of hip fractures in elderly Chinese: a matched case-control study.
J Clin Endocrinol Metab. 2013 Jun;98(6):2347-55
Authors: Zeng FF, Wu BH, Fan F, Xie HL, Xue WQ, Zhu HL, Chen YM
Abstract
CONTEXT: Many studies have investigated the effects of individual foods or nutrients on bone health, but limited research has focused on dietary patterns.
PURPOSE: We examined the association of dietary patterns with the risk of hip fractures in elderly Chinese.
DESIGN: This 1:1 age- (±3 years) and gender-matched case-control study were performed between June 2009 and June 2012.
SETTING: The study was conducted in Guangdong Province, China.
PARTICIPANTS: A total of 581 pairs of hip fracture incident cases and controls (71 ± 7 years) were studied. Face-to-face interviews were conducted to assess dietary intake using a 79-item food frequency questionnaire, whereas general information was collected using structured questionnaires. Dietary patterns were identified by a principal components factor analysis. Univariate and multivariate conditional logistic regression were used to analyze the association.

Sunday, 11 August 2013

Antitumor effect of Japanese apricot extract (MK615) on human cancer cells in vitro and in vivo through a reactive oxygen species-dependent mechanism.

Antitumor effect of Japanese apricot extract (MK615) on human cancer cells in vitro and in vivo through a reactive oxygen species-dependent mechanism.
Tumori. 2013 Mar-Apr;99(2):239-48
Authors: Hattori M, Kawakami K, Akimoto M, Takenaga K, Suzumiya J, Honma Y
Abstract
AIMS AND BACKGROUND: MK615 is produced from Japanese apricot and contains several cyclic triterpenes, such as oleanolic and ursolic acids. MK615 was shown to strongly suppress cutaneous in-transit metastasis in a patient with malignant melanoma. The present investigation was undertaken to clarify the antitumor effects of MK615 in vitro and in vivo.

Saturday, 10 August 2013

Hot flashes and cancer

Risk factors, pathophysiology, and treatment of hot flashes in cancer.
CA Cancer J Clin. 2013 May;63(3):167-92
Authors: Fisher WI, Johnson AK, Elkins GR, Otte JL, Burns DS, Yu M, Carpenter JS
Abstract
Hot flashes are prevalent and severe symptoms that can interfere with mood, sleep, and quality of life for women and men with cancer. The purpose of this article is to review existing literature on the risk factors, pathophysiology, and treatment of hot flashes in individuals with cancer. Electronic searches were conducted to identify relevant English-language literature published through June 15, 2012.

Friday, 9 August 2013

Application of spectrum-effect relationship in Chinese medicine research and related thinking

Application of spectrum-effect relationship in Chinese medicine research and related thinking].
Zhongguo Zhong Yao Za Zhi. 2013 Jan;38(1):26-31
Authors: Qin KM, Zheng LJ, Shen BJ, Zhang XH, Li H, Di LQ, Xu ZS, Cai BC
Abstract
Fingerprint technology is the key technology in modern Chinese medicine research, while spectrum-effect relationship research is the advanced stage of fingerprint research. Spectrum-effect relationship research can reveal the relationship between fingerprint and pharmacological effect through multiple statistical analyses, which can be used in Chinese medicine research. Spectrum-effect relationship has been used in many areas of Chinese medicine research, such as effective basis of single and compound Chinese medicine research, component compatibility research, processing mechanism research, pharmacological effect forecast research, technology optimization research, and so on. This paper systematically reviewed the application of spectrum-effect relationship in Chinese medicine research, and indicated some problems in spectrum-effect relationship research. At last, the authors give an outlook of the future of spectrum-effect relationship research.
PMID: 23596870 [PubMed - indexed for MEDLINE]

Thursday, 8 August 2013

Bone-setting in the Irish Tradition

Bone-setting has been recognized as an area of medical expertise from early times.
It has always been an integral part of life in Ireland, and is still practiced today. For
the present study, two well-known bone-setters were interviewed, and the
interviews analysed for underlying themes, including those of the practitioners’
perception of their role in society, the role of ‘the gift’ of bone-setting within their
respective practices, and the transmission of that gift. The skills and scope of
practice inherent in the profession were also examined. Issues surrounding both the
community’s and the medical profession’s perceptions of the bone-setter were also
addressed. It is evident that some loss of knowledge has occurred with the passing
of time, but it is here argued that the unique skills of the bone-setter could
potentially make a significant contribution to the primary health care service
To read this article click on
 http://www.ucc.ie/en/bealoideas/research/publications/journals/folklorejournal2013/

Wednesday, 7 August 2013

Molecular dynamics simulations of the interactions of medicinal plant extracts and drugs with lipid bilayer membranes.

Molecular dynamics simulations of the interactions of medicinal plant extracts and drugs with lipid bilayer membranes.
FEBS J. 2013 Jun;280(12):2785-805
Authors: Kopeć W, Telenius J, Khandelia H
Abstract
Several small drugs and medicinal plant extracts, such as the Indian spice extract curcumin, have a wide range of useful pharmacological properties that cannot be ascribed to binding to a single protein target alone. The lipid bilayer membrane is thought to mediate the effects of many such molecules directly via perturbation of the plasma membrane structure and dynamics, or indirectly by modulating transmembrane protein conformational equilibria.

Tuesday, 6 August 2013

Effect of Chinese herbs on immunoglobulin A nephropathy: a randomized controlled trial

Effect of Chinese herbs on immunoglobulin A nephropathy: a randomized controlled trial.
J Tradit Chin Med. 2013 Feb;33(1):65-9
Authors: Wei M, Xiong P, Zhang L
Abstract
OBJECTIVE: The accumulation of extracellular matrix (ECM) is one of the main causes of renal fibrosis. Emerging evidence suggests that the metabolic enzyme of ECM is associated with renal fibrosis. In this study, we applied randomly controlled trial to check the curative effect of Chinese herbs on patients with immunoglobulin A nephropathy (IgAN).
METHODS: Twenty-six patients were randomly divided into group A (control group) treated with Western Medicine and group B (treatment group) treated with combination of Traditional Chinese Medicine (TCM) and Western Medicine. Blood and urine tests were done before treatment and after 8-week treatment.
RESULTS: The levels of the main composition of extracellular matrix (MC-ECM), the metabolic enzyme of ECM (ME-ECM) and some cytokines in group B decreased more obviously than those in group A after 8-week treatment. So did the level of 24-hour urine protein. However, Metal matrix protease (MMP)-2 and vascular endothelial growth factor in group B increased more obviously than those in group A after 8-week treatment. No effects on the renal function were found in both groups.
CONCLUSION: Our study provided important information on using the combination of TCM with Western Medicine to inhibit the progression of renal fibrosis in patients with IgAN.
PMID: 23596814 [PubMed - indexed for MEDLINE

Monday, 5 August 2013

Targeting beta-Catenin signaling to induce apoptosis in human breast cancer cells by z-Guggulsterone and Gugulipid extract of Ayurvedic medicine plant Commiphora mukul

Targeting beta-Catenin signaling to induce apoptosis in human breast cancer cells by z-Guggulsterone and Gugulipid extract of Ayurvedic medicine plant Commiphora mukul

Authors: Guoqin JiangXiao XiaoYan ZengKalyanam NagabhushanamMuhammed Majeed andDong Xiao

Background

z-Guggulsterone (z-Gug) and Gugulipid (GL) have been used to treat a variety of ailments. We now report their anti-cancer effect and mechanism against human breast cancer.

Methods

Using the human estrogen receptor-positive (MCF-7) and triple-negative (MDA-MB-231) breast cancer cells as well as the normal human mammary epithelial cell line (HMEC), we evaluated the anti-breast-cancer efficacy and apoptosis inducing activity of GL. We determined the cellular and molecular mechanism of GL-inhibited breast cancer cell growth.

Results

GL significantly inhibited growth of MCF-7 and MDA-MB-231 cells with an IC50~2muM at pharmacologically relevant concentrations standardized to its major active constituent z-Gug. The GL-induced growth inhibition correlated with apoptosis induction as evidenced by an increase in cytoplasmic histone-associated DNA fragmentation and caspase 3 activity.

Sunday, 4 August 2013

Chinese herbs for memory disorders: a review and systematic analysis of classical herbal literature.

Chinese herbs for memory disorders: a review and systematic analysis of classical herbal literature.
J Acupunct Meridian Stud. 2013 Feb;6(1):2-11
Authors: May BH, Lu C, Lu Y, Zhang AL, Xue CC
Abstract
Text mining and other literature-based investigations can assist in identifying natural products for experimental and clinical research. This article details a method for systematically analyzing data derived from the classical Chinese medical literature. We present the results of electronic searches of Zhong Hua Yi Dian ("Encyclopaedia of Traditional Chinese Medicine"), a CD of 1000 premodern (before 1950) medical books, for single herbs, and other natural products used for dementia, memory disorders, and memory improvement.

Saturday, 3 August 2013

Plant food supplements with anti-inflammatory properties: a systematic review (II)

Plant food supplements with anti-inflammatory properties: a systematic review (II).
Crit Rev Food Sci Nutr. 2013;53(5):507-16
Authors: Di Lorenzo C, Dell'Agli M, Badea M, Dima L, Colombo E, Sangiovanni E, Restani P, Bosisio E
Abstract
The aim of this systematic review is to summarize the evidence for or against the efficacy of plant food supplements (PFS) for coping inflammatory conditions by considering epidemiological and human intervention studies. The review considers six botanical species commonly used as food supplements/medicinals: Urtica dioica L., Symphytum officinalis L., Calendula officinalis L., Curcuma longa L., Boswellia serrata Roxb., and Harpagophytum procumbens L. The search retrieved 579 publications. By removing the duplicates and applying the inclusion/exclusion criteria, the final number of papers was 47. No epidemiological data were found. The bibliographic search found no paper regarding the anti-inflammatory effects of Calendula officinalis L. and Symphytum officinalis L. by oral use. In spite of the long-term traditional use for inflammatory disorders, Curcuma longa L. and Harpagophytum procumbens L. warrant further investigation, whereas the efficacy of Urtica dioica L, even if the available data on hard endpoints are promising, requires other trials. Boswellia serrata Roxb. was found to be the most promising, since it shows the best efficacy for the treatment of pain/inflammatory conditions. In conclusion, it is advisable to conduct further studies with more homogeneous population and larger number of subjects by avoiding the heterogeneity of the herbal preparations considered.
PMID: 23391017 [PubMed - indexed for MEDLINE]

Friday, 2 August 2013

Attitude and practice of patients and doctors towards complementary and alternative medicine.

Attitude and practice of patients and doctors towards complementary and alternative medicine.
J Pak Med Assoc. 2012 Aug;62(8):865-8
Authors: Junaid R, Abaas M, Fatima B, Anis I, Hussain M
Abstract
OBJECTIVES: To determine the attitude towards complementary and alternative medicine among the doctors and patients.
METHODS: The study was carried out at Civil Hospital Karachi and Liaquat National University Hospital, Karachi during April to September 2010. Two sets of questionnaires were developed separately for doctors and patients. Each set consisted of queries regarding demographic data of patients and doctors. The questionnaire for the patients contained questions reflecting the general attitude, mode of complimentary and alternative medicine usage, disease referred and the underlined reasons behind pricking the options.

Thursday, 1 August 2013

Sambucus ebulus. - Anti-giardial activity

Anti-giardial activity of Sambucus ebulus.
Eur Rev Med Pharmacol Sci. 2013 Aug;17(15):2047-50
Authors: Rahimi-Esboei B, Ebrahimzadeh MA, Gholami Sh, Falah-Omrani V
Abstract
OBJECTIVES: Giardia (G.) lamblia is a parasite that causes giardiasis in humans and other mammals. The common treatment produces unpleasant side effects. The ethnopharmacology for management of parasitic infections accelerates and guides the search for new chemical objects. This study assessed the in vitro cytotoxicity of Sambucus (S.) ebulus fruit against Cysts of G. lamblia.
MATERIALS AND METHODS: Giardia cysts were isolated from patients' fecal specimens; the cysts were isolated by sucrose 0.85 M solution. The plant extract was used at concentrations of 1, 10, 50 and 100 mg/mL throughout the experiments. The extracts were incubated with several isolates of G. lamblia for 5, 10, 30 and 60 minutes and then the viability were distinguished by eosin 0.01%.
RESULTS: S. ebulus extract at the concentration of 100 mg/ml for 60 minutes had the most anti-giardial activity (78 ± 4%) than other concentrations.
CONCLUSIONS: Considering excellent antigiardial activity of S. ebulus in vitro, it seems to have potential for the treatment of the parasitic disease caused by the protozoan G. lamblia.