Rosmarinic Acid as a Novel Agent in the Treatment of Autoimmune DiseaseAug 12, 2013 03:00 am | Journal of Restorative Medicine
Autoimmune diseases are among the most challenging to treat. Conventional medical therapies are immunosuppressive agents that suppress symptoms, but also have undesirable side effects. An effective alternative therapy without these side effects would be extremely valuable. Rosmarinic acid, which has been used in multiple sclerosis and thyroid autoimmune disease, may be such an alternative therapy.
Rosmarinic acid has been shown to selectively induce T cell apoptosis in aberrant lymphocytes, but not normal/quiescent T cells. Rosmarinic acid also reduces gamma interferon driven T cell responses and reduces interleukin production following T cell stimulation. Furthermore, rosmarinic acid affects signal transduction inside T cells by affecting specific tyrosine kinase enzymes inside the cell. By direct effects on T cells as well as other anti-inflammatory and antioxidant effects, rosmarinic acid may be a safe and valuable tool for reducing autoimmune inflammation. It may also be safe and advantageous to use in tandem with pharmaceutical treatment of autoimmune diseases.
Rosmarinic Acid as a Novel Agent in the Treatment of Autoimmune Disease
at The Association for the Advancement of Restorative Medicine